If you mean that you want to extract every bit of performance that a server compute environment has, the only way you will achieve that is to have your own colocated hardware in a datacenter with no virtualization at all.
However, there are very few instances in which I would think that would be advantageous. You would get better performance and scalability by leveraging virtualization paired with horizontal scaling using either docker an elastic compute stack like AWS Beanstalk.
Or am I incorrect in the assumption of what your question is?