I'm using Homestead (latest) and utf8mb4 with no issue. I do not use Sequel Pro but are you sure it isn't Sequel Pro's issue? I've noticed in Sequel's GitHub issue area there are a few tickets related to utf8mb4.
Jun 18, 2020
4
Level 7
Is Homestead 10.0 beta broken?
I just updated my Homestead to 10.0 beta. My database causes Sequel Pro crashing on launch. I also don't understand what happened to the encoding. When I try to create a new database, here's what I get:

As you can see, all utf8mb4 are missing and there are lots of bizarre duplicates.
What happened? And how can I install stable version of Homestead? I don't understand why vagrant box update installs beta by default, it's ridiculous.
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