No, it'll be more like the opposite. MySQL can pretty much do everything that SQLite also can, but SQLite cannot and has limitations in certain areas. That is a good thing in a way, I guess.
You don't have to worry about such a thing, it won't be an issue.
We are actively using SQLite for tests and haven't had a major issue. (My experience) The test suite (aroun 2K tests) that normally should pass in 5-10 minutes takes less than a minute thanks to parallel testing and SQLite.
@sinnbeck You're welcome. There are some gotchas however, but still the sheer amount of speed when testing is worth all of the effort. e.g. You won't be able to just call Storage::fake to test storage, see this blog post