You mean two virtual machines, one managed with vagrant and a second independent one with XAMPP?
If that's the case, you shouldn't have any problems as each VM will have it's own IP address, so no ports collisions.
Now, if you are planning to install XAMPP at the same Vagrant VM...you probably won't need to install any additional services, but configure / enable the ones that Homestead provides.
Or you could just have 2 different vagrant instances...
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Hello @marianomoreyra ! Thank you for your time. I strictly want Xamp installed directly on my computer to run a project on local and to run another project with Vagrant. The question is if I can open both of them in the same time and there won't be errors.