I selected DigitalOCean for the back destrination but it looks like it's still using s3 in the error:
Streaming backups to storage...
mysqldump: [Warning] Using a password on the command line interface can be insecure.
upload failed: - to s3://aiha-assets/database-backups/20210325182350/aiha_production.sql.gz An error occurred (SignatureDoesNotMatch) when calling the CreateMultipartUpload operation: Unknown
Cleaning up backup.
Exit code 1 occurred on line 1
Well, the digital ocean storage system is built on the same protocol as S3. So basically they work the same, but they have a different URL and authentication method behind them.
Make sure to double-check the authentication part of your setup. It seems it's missing some keys here or you're using the wrong keys.