Best way to implement Roles and Permissions?

I'm using laravel backpack for a site with the permissionmanager from Spatie https://github.com/spatie/laravel-permission .

I have different roles, like admin, moderator, user, etc. What's the best way to implement the roles and permissions in my application?

Should I use middlewares? Should I call the constructor and check the permissions there? If I would use middleware, would I need to create middlewares for each permission I need to check, like a middleware for create, one for edit and one for delete? Admins for example can do litteraly everything. Moderators not and user just have a few permissions.

I really don't have a clue at the moment.

I'm using permissions for the first time so please apologize the noobish questions.

I'm thankfull for every advice/help.